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Metabolomics - a playbook for functional genomics

If we have learned anything from scientific research in the last 20 years, it is that finding cures to complex diseases is difficult. Despite the promise of the genomic revolution, disease progression and patient outcomes are still not easily predicted by genetic factors alone.

Editing the Human Genome: role in functional genomics and translational medicine. Summer 12

It is now readily accepted that we are in a post genomic era. With the steady flow of genomic information available to researchers worldwide, the focus turns to ways to analyse this information effectively and then utilise it in a practical manner.

target discovery and drug design: extracting the value from genomics

Pharmaceutical research and development is changing. The old model of drug discovery, based on a combination of imprecise candidate generation and broad physiological screens, has given way to more specific and intelligent approaches to target identification and drug design. Now, a vast influx of genomic information is set to revolutionise the range of targets available, at least to those able to navigate effectively through the bewildering immensity of the world’s genomic data archives.

Putting the code to work: the promise of pharmacogenetics and pharmacogenomics

Within the next 10 years the benefits of pharmacogenetics and pharmacogenomics will inevitably outweigh the disadvantages. But what are the commercial and legal implications for the pharmaceutical industry especially for companies who have lead candidates ready to enter development?

CHEMOGENOMICS a gene family approach to parallel drug discovery

Currently available drugs only target around 500 different proteins4. Recent reports from efforts to sequence the human genome suggest there are tens of thousands of genes1,2 and many more different proteins. Popular estimates of the number of ‘new’ drug targets that will emerge from genomic research range from 2,000 to 5,0003. A critical question as we enter the post-genomic world is: how can the pharmaceutical industry rapidly discover and develop medicines for these new targets to improve the human condition?

TOXICOGENOMICS insights into the present and future

Adverse drug responses are an important post-marketing public health issue, occurring many times in subsets of treatment populations. Promising new approaches to predicting physiological responses to drugs are focused on ‘genomic responses’ or toxicogenomics1. This article provides a current perspective on toxicogenomics technologies that are aimed at: 1) providing new tools and systems for more rapid, accurate and complete toxicity assessments in advance of human exposure; 2) enhancing the thoroughness and accuracy of toxicity assessments achievable with currently available test systems, and 3) predictive assessments of individualised risk for developing adverse drug reactions.

The emergence of pharmacogenomics within the pharmaceutical industry

sequencing of the human genome represents one of the most significant scientific advances of the 20th century that will shape the foundation of medical research well into the 21st.This accomplishment was enabled by remarkable technological advances – high throughput sequencing, increased computing power, automated methods of analysis – that 25 years ago seemed unimaginable.Through this project, we have gained the understanding that human beings are an estimated 99.9% identical at the genetic level.Yet, it is the 0.1% of variation among individuals that serves as the foundation for the emerging discipline of pharmacogenomics. It is this variation that contributes to physical diversity in the human population as well as differences in disease susceptibility and response to pharmacological therapies.This contribution of the Human Genome Project offers the opportunity to shape the face of drug discovery and development in this century.

High throughput genomics and drug discovery – parallel universes or a continuum?

HTS has been in place for approximately 10-12 years and has achieved a threeorder of magnitude scale up. Genomics has been in a ‘high throughput’ mode for approximately four years for areas such as genotyping, is an emerging field governed by sporadic technology leaps and data generation leaps. However, despite these approaches, there are many discrepancies and parallels that exist between the two areas: sample management/assay assembly/parallel processing/ data analysis. However, some differences exist with respect to regulatory issues, public perception and ethical consent. The article will compare and contrast these fields and highlight where both disciplines may learn from each other

High throughput genomics and drug discovery – parallel universes or a continuum?

HTS has been in place for approximately 10-12 years and has achieved a threeorder of magnitude scale up. Genomics has been in a ‘high throughput’ mode for approximately four years for areas such as genotyping, is an emerging field governed by sporadic technology leaps and data generation leaps. However, despite these approaches, there are many discrepancies and parallels that exist between the two areas: sample management/assay assembly/parallel processing/ data analysis. However, some differences exist with respect to regulatory issues, public perception and ethical consent. The article will compare and contrast these fields and highlight where both disciplines may learn from each other.

Drug development for skin diseases based on functional genomics

With the high number of sufferers from skin disease around the world, it is astonishing that there are relatively few treatments available and that many of these only serve to relieve symptoms. Can drug development based on a functional genomics approach be the answer in bringing new products to this ‘Cinderella’ market?

Tools for STRUCTURAL GENOMICS accelerating the structure pipeline. Summer 04

The international structural genomics effort has resulted in a number of technological advancements that are accelerating the process of threedimensional structure determination while continually decreasing the cost per structure.

STRUCTURAL Genomics drives demand for high throughput protein purification. Fall 04

The rapid growth in proteomic and structural and functional genomic research is driving demand for purified proteins that far exceeds the industry�s ability to scale-up conventional protein production technologies. This demand has sparked innovation in protein separation and purification technologies. We discuss how the advent of improved systems for protein expression and high throughput parallel protein purification can deliver the opportunity to ignite a revolution in structural and functional genomics, proteomics and high-value drug target discovery.

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                                      'article_title' => "High throughput genomics and drug discovery \x{96} parallel universes or a continuum?",
                                      'article_section_id' => '577',
                                      'article_subhead1' => 'By Dr Mark Beggs and Audrey Long',
                                      'path' => "/summer-2002/p148449-high-throughput-genomics-and-drug-discovery-\x{96}-parallel-universes-or-a-continuum.html",
                                      'article_excerpt' => "HTS has been in place for approximately 10-12 years and has achieved a threeorder of magnitude scale up. Genomics has been in a \x{91}high throughput\x{92} mode for approximately four years for areas such as genotyping, is an emerging field governed by sporadic technology leaps and data generation leaps. However, despite these approaches, there are many discrepancies and parallels that exist between the two areas: sample management/assay assembly/parallel processing/ data analysis. However, some differences exist with respect to regulatory issues, public perception and ethical consent. The article will compare and contrast these fields and highlight where both disciplines may learn from each other.",
                                      'article_section_title' => 'Summer 2002',
                                      'article_status' => '1',
                                      'spath' => '/summer-2002/',
                                      'article_subhead2' => 'Summer 2002',
                                      'article_inserted' => '2011-09-12 19:29:03',
                                      'section_status' => '1',
                                      'id' => '148449'
                                    },
                         '10003' => {
                                      'article_title' => 'Putting the code to work: the promise of pharmacogenetics and pharmacogenomics',
                                      'article_section_id' => '592',
                                      'article_subhead1' => 'By Dr Tim Peakman and Dr Steve Arlington',
                                      'path' => '/winter-2000/p148609-putting-the-code-to-work:-the-promise-of-pharmacogenetics-and-pharmacogenomics.html',
                                      'article_excerpt' => 'Within the next 10 years the benefits of pharmacogenetics and pharmacogenomics will inevitably outweigh the disadvantages. But what are the commercial and legal implications for the pharmaceutical industry especially for companies who have lead candidates ready to enter development?',
                                      'article_section_title' => 'Winter 2000',
                                      'article_status' => '1',
                                      'spath' => '/winter-2000/',
                                      'article_subhead2' => 'Winter 2000',
                                      'article_inserted' => '2011-10-27 15:16:11',
                                      'section_status' => '1',
                                      'id' => '148609'
                                    },
                         '10007' => {
                                      'article_title' => "High throughput genomics and drug discovery \x{96} parallel universes or a continuum?",
                                      'article_section_id' => '577',
                                      'article_subhead1' => 'By Dr Mark Beggs and Audrey Long',
                                      'path' => "/summer-2002/p148453-high-throughput-genomics-and-drug-discovery-\x{96}-parallel-universes-or-a-continuum.html",
                                      'article_excerpt' => "HTS has been in place for approximately 10-12 years and has achieved a threeorder of magnitude scale up. Genomics has been in a \x{91}high throughput\x{92} mode for approximately four years for areas such as genotyping, is an emerging field governed by sporadic technology leaps and data generation leaps. However, despite these approaches, there are many discrepancies and parallels that exist between the two areas: sample management/assay assembly/parallel processing/ data analysis. However, some differences exist with respect to regulatory issues, public perception and ethical consent. The article will compare and contrast these fields and highlight where both disciplines may learn from each other",
                                      'article_section_title' => 'Summer 2002',
                                      'article_status' => '1',
                                      'spath' => '/summer-2002/',
                                      'article_subhead2' => 'Summer 2002',
                                      'article_inserted' => '2011-09-12 20:22:46',
                                      'section_status' => '1',
                                      'id' => '148453'
                                    },
                         '10000' => {
                                      'article_title' => 'Metabolomics - a playbook for functional genomics',
                                      'article_media' => 'metabolomics-cropped.jpg',
                                      'article_section_id' => '356',
                                      'article_subhead1' => 'By Dr D Ferrick',
                                      'path' => '/enabling-technologies/p315008-metabolomics-a-playbook-for-functional-genomics.html',
                                      'article_excerpt' => 'If we have learned anything from scientific research in the last 20 years, it is that finding cures to complex diseases is difficult. Despite the promise of the genomic revolution, disease progression and patient outcomes are still not easily predicted by genetic factors alone.',
                                      'article_section_title' => 'Enabling Technologies',
                                      'article_status' => '1',
                                      'spath' => '/enabling-technologies/',
                                      'article_subhead2' => 'Summer 2016',
                                      'article_inserted' => '2016-07-15 17:07:41',
                                      'section_status' => '1',
                                      'id' => '315008'
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                         '10010' => {
                                      'article_title' => 'Tools for STRUCTURAL GENOMICS accelerating the structure pipeline.  Summer 04',
                                      'article_media' => 'tools-for-structural-genomics-accelerating-the-structure-pipeline.jpg',
                                      'article_section_id' => '356',
                                      'article_subhead1' => 'By Dr Lawrence J. DeLucas, Dr Christie G. Brouillette, Dr Kal Ramnarayan and Dr Shankari Mylvaganam',
                                      'path' => '/enabling-technologies/p148370-tools-for-structural-genomics-accelerating-the-structure-pipeline-summer-04.html',
                                      'article_excerpt' => 'The international structural genomics effort has resulted in a number of technological advancements that are accelerating the process of threedimensional structure determination while continually decreasing the cost per structure. ',
                                      'article_section_title' => 'Enabling Technologies',
                                      'article_status' => '1',
                                      'spath' => '/enabling-technologies/',
                                      'article_subhead2' => 'Summer 2004',
                                      'article_inserted' => '2011-08-27 15:27:36',
                                      'section_status' => '1',
                                      'id' => '148370'
                                    },
                         '10004' => {
                                      'article_title' => 'CHEMOGENOMICS a gene family approach to parallel drug discovery',
                                      'article_section_id' => '591',
                                      'article_subhead1' => 'By Dr Paul R. Caron, Dr Michael D. Mullican, Dr Robert D. Mashal, Dr Keith P. Wilson, Dr Michael S. Su and Dr Mark A. Murcko',
                                      'path' => '/fall-2001/p148597-chemogenomics-a-gene-family-approach-to-parallel-drug-discovery.html',
                                      'article_excerpt' => "Currently available drugs only target around 500 different proteins4. Recent reports from efforts to sequence the human genome suggest there are tens of thousands of genes1,2 and many more different proteins. Popular estimates of the number of \x{91}new\x{92} drug targets that will emerge from genomic research range from 2,000 to 5,0003. A critical question as we enter the post-genomic world is: how can the pharmaceutical industry rapidly discover and develop medicines for these new targets to improve the human condition?",
                                      'article_section_title' => 'Fall 2001',
                                      'article_status' => '1',
                                      'spath' => '/fall-2001/',
                                      'article_subhead2' => 'Fall 2001',
                                      'article_inserted' => '2011-10-27 11:03:05',
                                      'section_status' => '1',
                                      'id' => '148597'
                                    },
                         '10001' => {
                                      'article_title' => 'Editing the Human Genome: role in functional genomics and translational medicine.  Summer 12',
                                      'article_media' => 'editing-the-human-genome-role-in-functional-genomics-and-translational-medicine.jpg',
                                      'article_section_id' => '356',
                                      'article_subhead1' => 'By Dr Chris Torrance and Eric Rhodes',
                                      'path' => '/enabling-technologies/p149526-editing-the-human-genome:-role-in-functional-genomics-and-translational-medicine-summer-12.html',
                                      'article_excerpt' => 'It is now readily accepted that we are in a post genomic era. With the steady flow of genomic information available to researchers worldwide, the focus turns to ways to analyse this information effectively and then utilise it in a practical manner.',
                                      'article_section_title' => 'Enabling Technologies',
                                      'article_status' => '1',
                                      'spath' => '/enabling-technologies/',
                                      'article_subhead2' => 'Summer 2012',
                                      'article_inserted' => '2012-07-18 16:59:47',
                                      'section_status' => '1',
                                      'id' => '149526'
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                         '10011' => {
                                      'article_title' => 'STRUCTURAL Genomics drives demand for high throughput protein purification.  Fall 04',
                                      'article_media' => 'structural-genomics-drives-demand-for-high-throughput-protein-purification.jpg',
                                      'article_section_id' => '356',
                                      'article_subhead1' => 'By Karsten Fjarstedt',
                                      'path' => '/enabling-technologies/p148369-structural-genomics-drives-demand-for-high-throughput-protein-purification-fall-04.html',
                                      'article_excerpt' => "The rapid growth in proteomic and structural and functional genomic research is driving demand for purified proteins that far exceeds the industry\x{ef}\x{bf}\x{bd}s ability to scale-up conventional protein production technologies. This demand has sparked innovation in protein separation and purification technologies. We discuss how the advent of improved systems for protein expression and high throughput parallel protein purification can deliver the opportunity to ignite a revolution in structural and functional genomics, proteomics and high-value drug target discovery.",
                                      'article_section_title' => 'Enabling Technologies',
                                      'article_status' => '1',
                                      'spath' => '/enabling-technologies/',
                                      'article_subhead2' => 'Fall 2004',
                                      'article_inserted' => '2011-08-27 15:02:38',
                                      'section_status' => '1',
                                      'id' => '148369'
                                    },
                         '10006' => {
                                      'article_title' => 'The emergence of pharmacogenomics within the pharmaceutical industry',
                                      'article_section_id' => '578',
                                      'article_subhead1' => 'By Aidan Power, Suzin Webb, Dr Albert Seymour and Dr Patrice Milos',
                                      'path' => '/fall-2002/p148471-the-emergence-of-pharmacogenomics-within-the-pharmaceutical-industry.html',
                                      'article_excerpt' => "sequencing of the human genome represents one of the most significant scientific advances of the 20th century that will shape the foundation of medical research well into the 21st.This accomplishment was enabled by remarkable technological advances \x{96} high throughput sequencing, increased computing power, automated methods of analysis \x{96} that 25 years ago seemed unimaginable.Through this project, we have gained the understanding that human beings are an estimated 99.9% identical at the genetic level.Yet, it is the 0.1% of variation among individuals that serves as the foundation for the emerging discipline of pharmacogenomics. It is this variation that contributes to physical diversity in the human population as well as differences in disease susceptibility and response to pharmacological therapies.This contribution of the Human Genome Project offers the opportunity to shape the face of drug discovery and development in this century.",
                                      'article_section_title' => 'Fall 2002',
                                      'article_status' => '1',
                                      'spath' => '/fall-2002/',
                                      'article_subhead2' => 'Fall 2002',
                                      'article_inserted' => '2011-09-18 17:15:49',
                                      'section_status' => '1',
                                      'id' => '148471'
                                    },
                         '10009' => {
                                      'article_title' => 'Drug development for skin diseases based on functional genomics',
                                      'article_section_id' => '577',
                                      'article_subhead1' => "By Dr J\x{f6}rn-Peter Halle",
                                      'path' => '/summer-2002/p148447-drug-development-for-skin-diseases-based-on-functional-genomics.html',
                                      'article_excerpt' => "With the high number of sufferers from skin disease around the world, it is astonishing that there are relatively few treatments available and that many of these only serve to relieve symptoms. Can drug development based on a functional genomics approach be the answer in bringing new products to this \x{91}Cinderella\x{92} market?",
                                      'article_section_title' => 'Summer 2002',
                                      'article_status' => '1',
                                      'spath' => '/summer-2002/',
                                      'article_subhead2' => 'Summer 2002',
                                      'article_inserted' => '2011-09-12 19:03:48',
                                      'section_status' => '1',
                                      'id' => '148447'
                                    },
                         '10002' => {
                                      'article_title' => 'target discovery and drug design: extracting the value from genomics',
                                      'article_section_id' => '593',
                                      'article_subhead1' => 'By Professor Ken Powell, Deputy Director, Wolfson Institute for Biomedical Research',
                                      'path' => '/summer-2000/p148620-target-discovery-and-drug-design:-extracting-the-value-from-genomics.html',
                                      'article_excerpt' => "Pharmaceutical research and development is changing. The old model of drug discovery, based on a combination of imprecise candidate generation and broad physiological screens, has given way to more specific and intelligent approaches to target identification and drug design. Now, a vast influx of genomic information is set to revolutionise the range of targets available, at least to those able to navigate effectively through the bewildering immensity of the world\x{92}s genomic data archives.",
                                      'article_section_title' => 'Summer 2000',
                                      'article_status' => '1',
                                      'spath' => '/summer-2000/',
                                      'article_subhead2' => 'Summer 2000',
                                      'article_inserted' => '2011-10-27 17:43:19',
                                      'section_status' => '1',
                                      'id' => '148620'
                                    },
                         '10005' => {
                                      'article_title' => 'TOXICOGENOMICS insights into the present and future',
                                      'article_section_id' => '590',
                                      'article_subhead1' => 'By Dr Patrick J. Vojta, Vincent P. Kazmer and Dr Larry D. Kier',
                                      'path' => '/winter-2001/p148590-toxicogenomics-insights-into-the-present-and-future.html',
                                      'article_excerpt' => "Adverse drug responses are an important post-marketing public health issue, occurring many times in subsets of treatment populations. Promising new approaches to predicting physiological responses to drugs are focused on \x{91}genomic responses\x{92} or toxicogenomics1. This article provides a current perspective on toxicogenomics technologies that are aimed at: 1) providing new tools and systems for more rapid, accurate and complete toxicity assessments in advance of human exposure; 2) enhancing the thoroughness and accuracy of toxicity assessments achievable with currently available test systems, and 3) predictive assessments of individualised risk for developing adverse drug reactions.",
                                      'article_section_title' => 'Winter 2001',
                                      'article_status' => '1',
                                      'spath' => '/winter-2001/',
                                      'article_subhead2' => 'Winter 2001 ',
                                      'article_inserted' => '2011-10-25 19:10:36',
                                      'section_status' => '1',
                                      'id' => '148590'
                                    }
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