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TTP Plc and Sphere Fluidics introduce Cyto-Mine Single Cell Analysis System

TTP Plc, and Sphere Fluidics have announced the launch of the Cyto-Mine Single Cell Analysis System. The Cyto-Mine system automates single cell analysis, sorting, imaging and dispensing to help boost throughput and sensitivity throughout the biopharmaceutical discovery process.

Therapeutic Drug Repurposing, Repositioning and Rescue Part IV: Financial model and analysis.

There is a growing consensus that Drug Repurposing, Repositioning and Rescue (DRPx) impacts all stakeholders involved in the therapeutic drug sector.

New developments in single cell separation and analysis technologies.

Recent advances of single cell technologies are facilitating the opportunity to discern biological insights within individual cells and providing a means to reveal previously hidden relationships between individual cells within a population.

Multi-parameter flow cytometry technology advances for rare cell analysis and sorting. Summer 13

The study of rare cell populations is important to advance medical diagnostics and therapeutics. For many clinical studies, rare cell counts promise to provide valuable alternate end points; examples are circulating tumour cells in peripheral blood, tumour stem cells, endothelial cells in blood, hematopoietic progenitor cells and their subpopulations, antigen specific T-cells and foetal cells in maternal circulation.

Biological analysis and interpretation for improved research outcomes.

In the last few years, technological advancements in the life sciences have changed many ways in which we think about research. Next-generation sequencing, qPCR and microRNA offer new avenues to ask and answer research questions in more detail and in less time. However, much of the effort today centres around data gathering, and many researchers are realising that collecting massive quantities of data is not the same as biological discovery.

Pathway Analysis understanding the bridge between environmental cues and cellular response Spring 12

Understanding the function of a protein in the context of normal and abnormal cellular processes requires a comprehensive knowledge not only of its regulation but also of its role in signalling and metabolic networks in the cell. Malfunctioning signalling pathways can lead to a variety of pathologies, hence why they are particularly investigated in the oncology/cancer disease area.

Optimising well results in label-free analysis. Spring 12

Bearing in mind the cost and time required to conduct a screening campaign, it is of paramount importance that screening laboratory scientists process and analyse screen data as carefully and consistently as possible. This paper argues that data analysis software that is modular, process-based and supports visualisation and flexible result generation is essential.

gene function via th analysis of multi-pro

Affinity proteomic methods can translate genomic data into validated targets for drug discovery. Baits such as tagged gene product or small molecules obtained from cell-based assays are used to purify interacting proteins. These proteins are then identified by high sensitivity, high throughput mass spectrometric techniques. Successful examples of this novel method are discussed in this article, such as the discovery of key components of the prototypical NF-B inflammation pathway, which are now in drug screening programs.

Lead generation and lead optimisation: the value of linking HT co-structure analysis and HT chemistry

The coupling of High Throughput co-structure analysis with focused library generation is not only proving a powerful general tool in lead optimisation but also increasing the probability of successful discovery of high quality oral development compounds for targets that have been quite difficult for the pharmaceutical industry.

GENE EXPRESSION: analysis and drug R&D. Spring 04

It is clear that gene expression profiling systems have a role to play in many facets of drug discovery and development but several questions remain. We take a look at the use of DNA microarray for gene expression or expression profiling and how DNA chips are used for drug discovery and development as a whole.

HIGH CONTENT SCREENING emerging importance of novel reagents/probes and pathway analysis. Summer 05

The number of high content screens will increase by 50% over the coming year; signal pathway analysis was seen as the most relevant high content screening (HCS) application; with greatest interest in applying HCS coming from oncology groups. Novel reagent/probes and pathway analysis developments were considered as the tools and technology developments which will impact most on HCS over the next few years.These were the main findings of the recent market survey reviewed in this article and are used as a setting to discuss some of the latest technologies now being applied to HCS.

The coupling of TTP LabTech's Acumen eX3 with BellBrook's iuvo Chemotaxis Assay plate provides a solution for the high content screening analysis of neutrophil chemotaxis assays

In the modern drug discovery industry, the development of cell based assays for High Content Screening (HCS) is necessary for the efficient screening of compound libraries. Until recently, assays for the analysis of chemotactic responses were not amenable for use in high content cell-based assay approaches. However, recent developments have enabled the investigation of chemotactic responses to be applied in cell-based High Throughput Screening (HTS) assays.

Modular automation for screening: a cost/benefit analysis. Summer 09

Cost is now a key driver for pharmaceutical companies and in many respects shapes the capital, revenue and resource decisions that have to be made during the drug discovery process. Where companies are resource rich, the need for fully automated screening platforms is reduced and workstation-based systems tend to be more abundant.

Seeing is Believing: The Benefits of Visual Analysis in Research

There is a growing pressure in todays climate for pharmaceutical companies to find tomorrows wonder drugs and dominate the major market segments. Recently, they have also been under attack for poor research productivity, for failures in drug safety and for off-label marketing. The use of visual analysis could do much to improve their performance in research and across all areas of activity.

Where the (drug) action really is; progress in systems-based analysis of Cellular Signalling.

Drug discovery currently focuses on targeted approaches, relying on validation of the target as a disease driver. However, the underlying biological complexity of disease often frustrates these attempts at therapeutic intervention, resulting in high failure rates due to lack of efficacy.

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                         '10015' => {
                                      'article_title' => 'Where the (drug) action really is;  progress in systems-based analysis of Cellular Signalling.',
                                      'article_media' => 'where-the-drug-action-really-is.jpg',
                                      'article_section_id' => '345',
                                      'article_subhead1' => 'By Dr Jeffrey A. Radding',
                                      'path' => '/drug-discovery/p92820-where-the-(drug)-action-really-is;progress-in-systems-based-analysis-of-cellular-signalling.html',
                                      'article_excerpt' => 'Drug discovery currently focuses on targeted approaches, relying on validation of the target as a disease driver. However, the underlying biological complexity of disease often frustrates these attempts at therapeutic intervention, resulting in high failure rates due to lack of efficacy. ',
                                      'article_section_title' => 'Drug Discovery',
                                      'article_status' => '1',
                                      'spath' => '/drug-discovery/',
                                      'article_subhead2' => 'Spring 08',
                                      'article_inserted' => '2010-12-23 16:00:05',
                                      'section_status' => '1',
                                      'id' => '92820'
                                    },
                         '10007' => {
                                      'article_title' => 'Optimising well results in label-free analysis.  Spring 12',
                                      'article_media' => 'optimising-well-results-in-label-free-analysis.jpg',
                                      'article_section_id' => '359',
                                      'article_subhead1' => 'By Dr Stephan Heyse, Dr Oliver Leven and Dr Jon Tupy',
                                      'path' => '/screening/p149203-optimising-well-results-in-label-free-analysis-spring-12.html',
                                      'article_excerpt' => 'Bearing in mind the cost and time required to conduct a screening campaign, it is of paramount importance that screening laboratory scientists process and analyse screen data as carefully and consistently as possible. This paper argues that data analysis software that is modular, process-based and supports visualisation and flexible result generation is essential.',
                                      'article_section_title' => 'Screening',
                                      'article_status' => '1',
                                      'spath' => '/screening/',
                                      'article_subhead2' => 'Spring 2012',
                                      'article_inserted' => '2012-04-29 20:15:00',
                                      'section_status' => '1',
                                      'id' => '149203'
                                    },
                         '10004' => {
                                      'article_title' => 'Multi-parameter flow cytometry technology advances for rare cell analysis and sorting.  Summer 13',
                                      'article_media' => '1multi-parameter-flow-cytometry-technology.jpg',
                                      'article_section_id' => '356',
                                      'article_subhead1' => 'By David Gebhard and Dr Diether Recktenwald',
                                      'path' => '/enabling-technologies/p213496-multi-parameter-flow-cytometry-technology-advances-for-rare-cell-analysis-and-sorting-summer-13.html',
                                      'article_excerpt' => 'The study of rare cell populations is important to advance medical diagnostics and therapeutics. For many clinical studies, rare cell counts promise to provide valuable alternate end points; examples are circulating tumour cells in peripheral blood, tumour stem cells, endothelial cells in blood, hematopoietic progenitor cells and their subpopulations, antigen specific T-cells and foetal cells in maternal circulation. ',
                                      'article_section_title' => 'Enabling Technologies',
                                      'article_status' => '1',
                                      'spath' => '/enabling-technologies/',
                                      'article_subhead2' => 'Summer 2013',
                                      'article_inserted' => '2013-07-30 15:34:05',
                                      'section_status' => '1',
                                      'id' => '213496'
                                    },
                         '10012' => {
                                      'article_title' => 'The coupling of TTP LabTech\'s Acumen eX3 with BellBrook\'s iuvo Chemotaxis Assay plate provides a solution for the high content screening analysis of neutrophil chemotaxis assays ',
                                      'article_section_id' => '451',
                                      'path' => '/high-content-screening/p147595-the-coupling-of-ttp-labtech-s-acumen-ex3-with-bellbrook-s-iuvo-chemotaxis-assay-plate-provides-a-solution-for-the-high-content-screening-analysis-of-neutrophil-chemotaxis-assays.html',
                                      'article_excerpt' => 'In the modern drug discovery industry, the development of cell based assays for High Content Screening (HCS) is necessary for the efficient screening of compound libraries. Until recently, assays for the analysis of chemotactic responses were not amenable for use in high content cell-based assay approaches. However, recent developments have enabled the investigation of chemotactic responses to be applied in cell-based High Throughput Screening (HTS) assays. ',
                                      'article_section_title' => 'High Content Screening',
                                      'article_status' => '1',
                                      'spath' => '/high-content-screening/',
                                      'article_inserted' => '2011-07-14 11:48:36',
                                      'section_status' => '1',
                                      'id' => '147595'
                                    },
                         '10001' => {
                                      'article_title' => 'Therapeutic Drug Repurposing, Repositioning and Rescue Part IV: Financial model and analysis. ',
                                      'article_media' => 'drug-repurposing.png',
                                      'article_section_id' => '345',
                                      'article_subhead1' => 'By David M. Kauppi and Dr Stephen Naylor',
                                      'path' => '/drug-discovery/p305522-therapeutic-drug-repurposingrepositioning-and-rescue-part-iv:-financial-model-and-analysis.html',
                                      'article_excerpt' => 'There is a growing consensus that Drug Repurposing, Repositioning and Rescue (DRPx) impacts all stakeholders involved in the therapeutic drug sector. ',
                                      'article_section_title' => 'Drug Discovery',
                                      'article_status' => '1',
                                      'spath' => '/drug-discovery/',
                                      'article_subhead2' => 'Winter 2015/16',
                                      'article_inserted' => '2016-02-06 15:32:45',
                                      'section_status' => '1',
                                      'id' => '305522'
                                    },
                         '10013' => {
                                      'article_title' => 'Modular automation for screening: a cost/benefit analysis.  Summer 09',
                                      'article_media' => 'modular-automation-for-screening-a-cost-benefit-analysis.jpg',
                                      'article_section_id' => '359',
                                      'article_subhead1' => 'By Dr Jonathan Wingfield',
                                      'path' => '/screening/p146754-modular-automation-for-screening:-a-cost/benefit-analysis-summer-09.html',
                                      'article_excerpt' => 'Cost is now a key driver for pharmaceutical companies and in many respects shapes the capital, revenue and resource decisions that have to be made during the drug discovery process. Where companies are resource rich, the need for fully automated screening platforms is reduced and workstation-based systems tend to be more abundant. ',
                                      'article_section_title' => 'Screening',
                                      'article_status' => '1',
                                      'spath' => '/screening/',
                                      'article_subhead2' => 'Summer 2009',
                                      'article_inserted' => '2011-06-26 16:20:39',
                                      'section_status' => '1',
                                      'id' => '146754'
                                    },
                         '10011' => {
                                      'article_title' => 'HIGH CONTENT SCREENING emerging importance of novel reagents/probes and pathway analysis.  Summer 05',
                                      'article_section_id' => '359',
                                      'article_subhead1' => 'By Dr John Comley',
                                      'path' => '/screening/p148339-high-content-screening-emerging-importance-of-novel-reagents/probes-and-pathway-analysis-summer-05.html',
                                      'article_excerpt' => 'The number of high content screens will increase by 50% over the coming year; signal pathway analysis was seen as the most relevant high content screening (HCS) application; with greatest interest in applying HCS coming from oncology groups. Novel reagent/probes and pathway analysis developments were considered as the tools and technology developments which will impact most on HCS over the next few years.These were the main findings of the recent market survey reviewed in this article and are used as a setting to discuss some of the latest technologies now being applied to HCS.',
                                      'article_section_title' => 'Screening',
                                      'article_status' => '1',
                                      'spath' => '/screening/',
                                      'article_subhead2' => 'Sumemr 2005',
                                      'article_inserted' => '2011-08-26 14:53:54',
                                      'section_status' => '1',
                                      'id' => '148339'
                                    },
                         '10014' => {
                                      'article_title' => 'Seeing is Believing: The Benefits of Visual Analysis in Research',
                                      'article_media' => 'seeing-is-believing.jpg',
                                      'article_section_id' => '357',
                                      'article_subhead1' => 'By Dr Christopher Ahlberg',
                                      'path' => '/informatics/p97054-seeing-is-believing:-the-benefits-of-visual-analysis-in-research.html',
                                      'article_excerpt' => 'There is a growing pressure in todays climate for pharmaceutical companies to find tomorrows wonder drugs and dominate the major market segments. Recently, they have also been under attack for poor research productivity, for failures in drug safety and for off-label marketing. The use of visual analysis could do much to improve their performance in research and across all areas of activity.',
                                      'article_section_title' => 'Informatics',
                                      'article_status' => '1',
                                      'spath' => '/informatics/',
                                      'article_subhead2' => 'Summer 2006',
                                      'article_inserted' => '2011-01-22 15:50:25',
                                      'section_status' => '1',
                                      'id' => '97054'
                                    },
                         '10002' => {
                                      'article_title' => 'New developments in single cell separation and analysis technologies.',
                                      'article_media' => 'single-cell-separation-2.jpg',
                                      'article_section_id' => '356',
                                      'article_subhead1' => 'By Dr John Comley Drug Discovery',
                                      'path' => '/enabling-technologies/p304818-new-developments-in-single-cell-separation-and-analysis-technologies.html',
                                      'article_excerpt' => 'Recent advances of single cell technologies are facilitating the opportunity to discern biological insights within individual cells and providing a means to reveal previously hidden relationships between individual cells within a population. ',
                                      'article_section_title' => 'Enabling Technologies',
                                      'article_status' => '1',
                                      'spath' => '/enabling-technologies/',
                                      'article_subhead2' => 'Fall 2015',
                                      'article_inserted' => '2015-10-26 17:26:04',
                                      'section_status' => '1',
                                      'id' => '304818'
                                    },
                         '10008' => {
                                      'article_title' => 'gene function via th analysis of multi-pro',
                                      'article_section_id' => '593',
                                      'article_subhead1' => 'By Matthias Mann, Protein Interaction Laboratory (PIL), University of Southern Denmark',
                                      'path' => '/summer-2000/p148612-gene-function-via-th-analysis-of-multi-pro.html',
                                      'article_excerpt' => 'Affinity proteomic methods can translate genomic data into validated targets for drug discovery. Baits such as tagged gene product or small molecules obtained from cell-based assays are used to purify interacting proteins. These proteins are then identified by high sensitivity, high throughput mass spectrometric techniques. Successful examples of this novel method are discussed in this article, such as the discovery of key components of the prototypical NF-B inflammation pathway, which are now in drug screening programs.',
                                      'article_section_title' => 'Summer 2000',
                                      'article_status' => '1',
                                      'spath' => '/summer-2000/',
                                      'article_subhead2' => 'Summer 2000',
                                      'article_inserted' => '2011-10-27 16:04:16',
                                      'section_status' => '1',
                                      'id' => '148612'
                                    },
                         '10003' => {
                                      'article_title' => 'Bioanalysis of Oxytocin Using a Microfluid LC/MS Platform',
                                      'article_media' => 'still-photo.jpg',
                                      'article_section_id' => '470',
                                      'path' => '/ddw-video-store/p217580-bioanalysis-of-oxytocin-using-a-microfluid-lc/ms-platform.html',
                                      'article_section_title' => 'DDW Video Store',
                                      'article_status' => '1',
                                      'spath' => '/ddw-video-store/',
                                      'article_inserted' => '2014-04-26 17:51:51',
                                      'section_status' => '1',
                                      'id' => '217580'
                                    },
                         '10000' => {
                                      'article_title' => 'TTP Plc and Sphere Fluidics introduce Cyto-Mine Single Cell Analysis System',
                                      'article_media' => 'cyto-mine-interior-image.jpg',
                                      'article_section_id' => '361',
                                      'path' => '/product-news/p320784-ttp-plc-and-sphere-fluidics-introduce-cyto-mine-single-cell-analysis-system.html',
                                      'article_excerpt' => 'TTP Plc, and Sphere Fluidics have announced the launch of the Cyto-Mine Single Cell Analysis System. The Cyto-Mine system automates single cell analysis, sorting, imaging and dispensing to help boost throughput and sensitivity throughout the biopharmaceutical discovery process.',
                                      'article_section_title' => 'Product & Industry News',
                                      'article_status' => '1',
                                      'spath' => '/product-news/',
                                      'article_inserted' => '2017-10-17 12:38:40',
                                      'section_status' => '1',
                                      'id' => '320784'
                                    },
                         '10010' => {
                                      'article_title' => 'GENE EXPRESSION:  analysis and drug R&D.  Spring 04',
                                      'article_section_id' => '356',
                                      'article_subhead1' => 'By Dr Ralph Sinibaldi',
                                      'path' => '/enabling-technologies/p148383-gene-expression:analysis-and-drug-r&d-spring-04.html',
                                      'article_excerpt' => 'It is clear that gene expression profiling systems have a role to play in many facets of drug discovery and development but several questions remain. We take a look at the use of DNA microarray for gene expression or expression profiling and how DNA chips are used for drug discovery and development as a whole.',
                                      'article_section_title' => 'Enabling Technologies',
                                      'article_status' => '1',
                                      'spath' => '/enabling-technologies/',
                                      'article_subhead2' => 'Spring 2004',
                                      'article_inserted' => '2011-08-31 09:20:32',
                                      'section_status' => '1',
                                      'id' => '148383'
                                    },
                         '10006' => {
                                      'article_title' => 'Pathway Analysis understanding the bridge between environmental cues and cellular response  Spring 12',
                                      'article_media' => 'pathway-analysis.jpg',
                                      'article_section_id' => '345',
                                      'article_subhead1' => 'By Dr John Comley',
                                      'path' => '/drug-discovery/p149204-pathway-analysis-understanding-the-bridge-between-environmental-cues-and-cellular-responsespring-12.html',
                                      'article_excerpt' => 'Understanding the function of a protein in the context of normal and abnormal cellular processes requires a comprehensive knowledge not only of its regulation but also of its role in signalling and metabolic networks in the cell. Malfunctioning signalling pathways can lead to a variety of pathologies, hence why they are particularly investigated in the oncology/cancer disease area. ',
                                      'article_section_title' => 'Drug Discovery',
                                      'article_status' => '1',
                                      'spath' => '/drug-discovery/',
                                      'article_subhead2' => 'Spring 2012',
                                      'article_inserted' => '2012-04-29 20:28:19',
                                      'section_status' => '1',
                                      'id' => '149204'
                                    },
                         '10009' => {
                                      'article_title' => 'Lead generation and lead optimisation: the value of linking HT co-structure analysis and HT chemistry',
                                      'article_section_id' => '576',
                                      'article_subhead1' => "By Dr David U\x{92}Prichard",
                                      'path' => '/spring-2002/p148443-lead-generation-and-lead-optimisation:-the-value-of-linking-ht-co-structure-analysis-and-ht-chemistry.html',
                                      'article_excerpt' => 'The coupling of High Throughput co-structure analysis with focused library generation is not only proving a powerful general tool in lead optimisation but also increasing the probability of successful discovery of high quality oral development compounds for targets that have been quite difficult for the pharmaceutical industry.',
                                      'article_section_title' => 'Spring 2002',
                                      'article_status' => '1',
                                      'spath' => '/spring-2002/',
                                      'article_subhead2' => 'Spring 2002',
                                      'article_inserted' => '2011-09-12 18:05:34',
                                      'section_status' => '1',
                                      'id' => '148443'
                                    },
                         '10005' => {
                                      'article_title' => 'Biological analysis and interpretation for improved research outcomes.',
                                      'article_media' => 'biological-analysis-and-interpretation-for-improved-research-outcomes.jpg',
                                      'article_section_id' => '357',
                                      'article_subhead1' => 'By Dr Douglas Bassett',
                                      'path' => '/informatics/p149219-biological-analysis-and-interpretation-for-improved-research-outcomes.html',
                                      'article_excerpt' => 'In the last few years, technological advancements in the life sciences have changed many ways in which we think about research. Next-generation sequencing, qPCR and microRNA offer new avenues to ask and answer research questions in more detail and in less time. However, much of the effort today centres around data gathering, and many researchers are realising that collecting massive quantities of data is not the same as biological discovery.',
                                      'article_section_title' => 'Informatics',
                                      'article_status' => '1',
                                      'spath' => '/informatics/',
                                      'article_subhead2' => 'Spring 2012',
                                      'article_inserted' => '2012-04-30 11:25:50',
                                      'section_status' => '1',
                                      'id' => '149219'
                                    }
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$VAR6 = 'id';
$VAR7 = '';
$VAR8 = '';
user session:
$VAR1 = '';