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Recent Advances in HCS LaserR Scanning Cytometry
By Dr John Comley
Laser scanning cytometers have matured over the past decade to meet the needs of end-users for higher throughput cell analysis, to access to previously difficult applications and to keep pace with the diversity of new fluorophores, validated high content screening (HCS) assay kits and reagents now available.
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High Throughput Screening, High Content Screening, Primary and Stem Cells
By Dr Richard M. Eglen
Over the past decade, the use of cell-based assays has accelerated in modern drug discovery. Indeed, the majority of assays in either target validation or lead identification/optimisation all now employ cell-based technologies.
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Progress in the Implementation of Label-Free Detection - part 1: cell-based assays
Summer 08
Progress made in the use of impedance and optical grating technologies for label-free detection of cell-based assays where examined in HTStec’s recent Cell-Based Label-Free Detection Trends 2008 report.
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Integrating HTS and fragment-based drug discovery
Summer 2008
High-Throughput Screening and Fragment Based Drug Discovery have been considered as alternative approaches to drug discovery for enzyme targets.
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Screening the Human Kinome, Expectations Met or Promises Pending?
Summer 2008
Protein kinases are important targets in drug discovery programmes aimed at treating cancer, autoimmune disorders, diabetes and neurological disorders.
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High throughput screening in academia drug discovery initiatives at the University of Kansas
By Dr Peter R. McDonald, Dr Anuradha Roy, Byron Taylor, Ashleigh Price, Dr Sitta Sittampalam, Dr Scott Weir and Dr Rathnam Chaguturu
Academia has historically been involved in exploring the fundamental aspects of the disease targets and in developing tool molecules to better understand the genetic, biological and biochemical basis of new and novel therapeutic targets.
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Ho Low Can You Go?
Fall 2008 edition
Proteins are the machinery that drive most biological processes; however, measuring their concentrations at low levels has been historically impeded by a lack of appropriately sensitive technology.
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Kinase Screening and Profiling - spoilt for choice.
By Dr John Comley
Overall, the end user is spoilt for choice with the range of alternative offerings, methodologies and approaches currently available for kinase screening and profiling.
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