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Progress in the Implementation of Label-Free Detection - part 1: cell-based assays. Summer 08

Summer 08
Progress made in the use of impedance and optical grating technologies for label-free detection of cell-based assays where examined in HTStec’s recent Cell-Based Label-Free Detection Tr...
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Integrating HTS and fragment-based drug discovery. Summer 08

Summer 2008
High-Throughput Screening and Fragment Based Drug Discovery have been considered as alternative approaches to drug discovery for enzyme targets
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Screening the Human Kinome, Expectations Met or Promises Pending? Summer 08

Summer 2008
Protein kinases are important targets in drug discovery programmes aimed at treating cancer, autoimmune disorders, diabetes and neurological disorders.
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High throughput screening in academia drug discovery initiatives at the University of Kansas Fall 08

By Dr P McDonald, Dr Roy, Byron Taylor, Ashleigh Price, Dr Sittampalam, Dr Scott Weir, Dr Chaguturu
Academia has historically been involved in exploring the fundamental aspects of the disease targets and in developing tool molecules to better understand the genetic, biological and bioch...
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Ho Low Can You Go? Fall 08

By Dr John Todd and Dr Sara J. Agee
Proteins are the machinery that drive most biological processes; however, measuring their concentrations at low levels has been historically impeded by a lack of appropriately sensitive t...
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Kinase Screening and Profiling - spoilt for choice. Winter 06

By Dr John Comley
Overall, the end user is spoilt for choice with the range of alternative offerings, methodologies and approaches currently available for kinase screening and profiling.
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Ion Channel Drug Targets; unlocking the potential. Summer 06

By Dr Dayle S. Hogg, Dr Philip Boden, Dr Geoff Lawton and Dr Roland Z. Kozlowski
A striking number of drugs targeting ion channels have reached blockbuster status, generating $ billion revenues. In spite of the historical success of ion channels as therapeutic targets... Read more...

Changing dynamics in dispense and imaging assays. Summer 2006

By Dr John Comley
The prospects for a significant shift in dispense and imaging (D&I) assays towards a greater utilisation of calcium-mediated flash luminescence readoutsappears to be finally under way. Dr... Read more...

Miniaturisation of assay development and screening. Summer 2006

By Andreas Boettcher and Dr Lorenz M. Mayr
In recent years we have seen a strong increase in the number of chemical compounds and molecular targets used for lead discovery by high-throughput screening among most Pharma and Biotech... Read more...

Convfocal widefield high content imaging. Fall 06

By Dr John Comley
A variety of new confocal hardware and software solutions have recently become available to support high content imaging. Most of the solutions have in common the potential of rejecting o... Read more...

Nanotechnology in high throughput screening. Fall 06

By Dr Bobak Azamian and Flora Tang
Nanotechnology has touched many scientific disciplines, from its roots in chemistry and physics to applications in biology and engineering1.A nanotechnology industry has developed, offeri... Read more...

Automated Patch Clamping: setting a new standard for early hERG. Winter 05

By Dr John Comley
Ion channel targets remain a top priority for many Pharma and Biotechs with most looking to increase their screening efforts in 2006.The impact of automated patch clamping (APC) on ion ch... Read more...