Ubiquitination, E3 ligases and drug discovery Novel technologies for a challenging pathway. Summer 12By Dr Neil Wilkie and Dr Steve Davies Does ubiquitin drug discovery provide the opportunity for a new class of therapeutic agents? This article argues that new technological advances are removing many of the barriers that hav...
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Pathway Analysis understanding the bridge between environmental cues and cellular response Spring 12By Dr John Comley Understanding the function of a protein in the context of normal and abnormal cellular processes requires a comprehensive knowledge not only of its regulation but also of its role in sign...
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Targeting target cancer metabolism what is fuelling the resurgence? Fall 11By Dr Neil P. Jones Targeting the metabolic pathways of cancer is a hot topic for drug discovery. The central dogma is that cancers have a higher demand for metabolic inputs to aid proliferation and survival...
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The need for high throughput kinetics early in the drug discovery process. Summer 11Dr Wilma Keighley Generally kinetics are only investigated late in a programme by which time many compounds, slightly less potent but with a much better kinetic profile, have already been discarded. This p...
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Balancing a biologics pipeline portfolio. Spring 11By Dr Herren Wu Research into groundbreaking biologic therapies has significantly shifted the diagnosis and treatment paradigms for many disease categories, particularly in oncology, autoimmune, inflamma...
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Induced pluripotent stem cells: a model for transforming drug discovery. Winter 10By Dr Dwight Morrow and Dr Julie Holder Induced pluripotent stem (iPS) cells have the potential to transform drug discovery by providing physiologically relevant cells for toxic compound identification, target validation, compo...
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Neutron scattering provides unique insights for drug R&D. Fall 10By Dr Martyn Bull Drug discovery and development is a long and expensive process. Techniques, such as computer modelling, that make the search for promising candidates easier are usually taken up enthusias...
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Overcoming Bottlenecks in drug discovery. Fall 10By Dr Trevor Perrior Developing a new drug is an expensive and time-consuming process. The best current estimate puts the cost of developing a single new drug at close to $1 billion1. After a drug candidate h...
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