Balancing a biologics pipeline portfolio. Spring 11By Dr Herren Wu Research into groundbreaking biologic therapies has significantly shifted the diagnosis and treatment paradigms for many disease categories, particularly in oncology, autoimmune, inflamma...
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Induced pluripotent stem cells: a model for transforming drug discovery. Winter 10By Dr Dwight Morrow and Dr Julie Holder Induced pluripotent stem (iPS) cells have the potential to transform drug discovery by providing physiologically relevant cells for toxic compound identification, target validation, compo...
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Neutron scattering provides unique insights for drug R&D. Fall 10By Dr Martyn Bull Drug discovery and development is a long and expensive process. Techniques, such as computer modelling, that make the search for promising candidates easier are usually taken up enthusias...
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Overcoming Bottlenecks in drug discovery. Fall 10By Dr Trevor Perrior Developing a new drug is an expensive and time-consuming process. The best current estimate puts the cost of developing a single new drug at close to $1 billion1. After a drug candidate h...
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3D Cell Culture: easier said than done! Summer 10By Dr John Comley The transition from cell culture on the flat surface of a conventional twodimensional (2D) culture vessel to a three-dimensional (3D) environment, matrix or scaffold with 3D architecture ...
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Innovation in drug discovery technology. Winter 09By Dr Al Kolb Drug Discovery Technology has been a major driver of advances in drug discovery. Automation, nanofluidics, imaging, software and assay technologies have played a major role in getting better data, faste...
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Free online resources enabling crowd-sourced drug discovery. Winter 09By Dr Antony J. Williams, Valery Tkachenko, Dr Chris Lipinski, Professor Alexander Tropsha and Dr Sean Ekins The availability of freely accessible online resources to enable and support drug discovery has blossomed in recent years. The PubChem platform is now accompanied by a myriad of other onl...
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Design Of Experiments: useful statistical tool in assay development or vendor disconnect! Winter 09By Dr John Comley The use of design of experiments (DOE) in assay development (AD) has the potential to speed up assay optimisation (ie reduce assay development bottlenecks) and to facilitate a more thorou...
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