Image Based Quantification of Neurite Outgrowth using The Opera

Endothelins (ETs) are a class of peptide hormones with strong vasoactive properties. ETs function by interacting with their G protein-coupled receptors (GPCRs). There are two known ET subtypes, ETA and ETB. The ETA receptor (ETAR) is localized on the plasma membrane until stimulated by endothelins such as endothelin-1 (ET-1), towards which ETAR shows the highest binding affinity. ET-1 triggers ETAR internalization into pericentriolar recycling endosomes.......

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