High Content Screening
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Homogeneous Binding Assay for High Throughput Antibody Screening
The study of antibodies against a wide range of protein targets is an expanding area for both antibody-based immunodiagnostic applications and therapies for diseases such as cancer and autoimmune disorders. Monoclonal antibodies are generated by cell lines that secrete specific antibodies into the growth media and rapid, sensitive screening of supernatants for these antibodies is central to the drug development programme.

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The use of Acumen' eX3 for the identification of the roles of Protein Kinase C and isoforms in PMA-induced HB-EGF ectodomain shedding EGFR ligands and their role in disease
EGFR ligands are a family of proteins which are involved in the regulation
of cell growth and differentiation and their over-expression is associated
with a number of cancers, including breast, lung and colon cancer. These
ligands are expressed on the cell surface and include proteins such
as epidermal growth factor (EGF), heparin binding EGF (HB-EGF) and
transforming growth factor ? (TGF?).

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A multiplexed cell-based assay for antibody screening against cell surface receptors.
The use of monoclonal antibodies against a wide range of protein targets is an expanding area for the development of therapies and biomarkers of diseases such as cancer and autoimmune disorders.

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The coupling of TTP LabTech's Acumen eX3 with BellBrook's iuvo Chemotaxis Assay plate provides a solution for the high content screening analysis of neutrophil chemotaxis assays
In the modern drug discovery industry, the development of cell based assays for High Content Screening (HCS) is necessary for the efficient screening of compound libraries. Until recently, assays for the analysis of chemotactic responses were not amenable for use in high content cell-based assay approaches. However, recent developments have enabled the investigation of chemotactic responses to be applied in cell-based High Throughput Screening (HTS) assays.

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Image Based Quantification of Neurite Outgrowth using The Opera
Endothelins (ETs) are a class of peptide hormones with strong vasoactive properties. ETs function by interacting with their G protein-coupled receptors (GPCRs). There are two known ET subtypes, ETA and ETB. The ETA receptor (ETAR) is localized on the plasma membrane until stimulated by endothelins such as endothelin-1 (ET-1), towards which ETAR shows the highest binding affinity. ET-1 triggers ETAR internalization into pericentriolar recycling endosomes.......

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Imaged Based Quanification Endo A Receptor Translocation using The Opera
The regeneration of neurons represents a promising strategy for drugs targeted against neurodegenerative injuries and disorders such as Alzheimer’s and Parkinson’s disease. Therefore, the development of new therapies is focused on
identifying molecules that affect the differentiation of neurons and neurite outgrowth. For this purpose automated measurement and analysis of neuronal cells is essential for neuroscience research and drug discovery......

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High Content Screening
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