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Comprehensive Assessment of Biosimilarity of Protein Biotherapeutics Based on Ion Signal Statistics

Stephanie Houel of Waters presents an integrated workflow to assess the biosimilarity between an innovator Etanercept and two biosimilar drugs at the ion level based on LC/MSE peptide mapping data.

LC/MS peptide mapping data is commonly used for assessing biosimilarity of biotherapeutics. The comparison based on identified component is a time-consuming process and requires a detailed examination of the data.