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Utilizing Ion Mobility Drift Times to Correlate and Track Metabolites Across Changing Chromatographi

Hernando Olivos of Waters illustrates the ability to use drift time ion mobility measurements to correlate isobaric species across chromatographic modes with changing retention times and elution orders.

One of the complexities found in drug development is the large diversity of analytical conditions used across users, labs and departments. Depending on the nature of the pharmacological question being addressed, the matrix being analyzed, selectivity needs, sensitivity needs and throughput needs, several chromatographic modes or methods may be utilized.