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Diverging paths, difficult choices. Winter 2012

By Dr Steve Arlington and Dr Nick Davies
Pharma is poised on a knife-edge. Major scientific and technological advances, together with socio-demographic changes, rising demand for medicines and trade liberalisation, will revive i...

Asian innovation: a unique opportunity for the pharmaceutical industry. Fall 12

By Dr Yi Gu and William Shi
As the third-largest market for the pharmaceutical industry, the China/Asia region is becoming increasingly important. The AstraZeneca Innovation Center China (ICC) in Shanghai is perfect...

The challenges of the changing drug discovery model. Fall 12

By Dr Mark Downs and Dr Tom Blackburn
The drug development industry is restructuring worldwide. This brings different ways of working and new challenges. As the industry moves away from internally focused research to an exter...

Innovate while derisking drug development: yes we can! Summer 12

Taher Abbasi, Pradeep Fernandes, Dr Shireen Vali and Professor Gurkirpal Singh
The outlook for the drug industry continues to remain bleak in context of productivity and success rates. In spite of ongoing increase in R&D expenses and technology revolutions in the ge...

A life sciences powerhouse: Ontario, Canada's story. Spring 12

By Michael Stewart
Around the world, competition between life sciences companies is fierce. And so is the competition between jurisdictions wanting to attract the good paying jobs, innovative spirit and R&D...

From outsourced to open: the continuing evolution of the drug discovery business model. Spring 12

Dr Mary Canady
One doesn't have to look far to find that the large pharmaceutical business model has many market forces working against it, such as patent expirations, dwindling pipelines, and reduced R...




The apocalyptic horsemen of drug discovery and development. Winter 11

By Dr Gary J. Keil
The pharmaceutical industry should consider an evolutionary disease management approach based on homeostasis, irreversibility, biological alinearity, pseudo-N-of-1 health and disease stat...

A roadmap for achieving self-sustainability of academic high throughput screening core facilities. Winter 11

By Dr Peter R. McDonald, Dr Anuradha Roy and Dr Rathnam Chaguturu
Many academic HTS centres, faced with the high costs of drug discovery and decreasing federal funding, are struggling to survive. Just as with any small business, a sound business plan is...

What are the obstacles to innovation in the pharmaceutical industry? Summer 11

The Pistoia Alliance
Innovation is a key word throughout the pharmaceutical industry and the healthcare community1 and its pursuit is a business imperative for Pharma.

The benefits of drug repositioning. Spring 11

By Dr Aris Persidis
Drugs in development, on the market, or those that are shelved because of lack of efficacy, are excellent starting points for further development. Finding new indications for such drugs w...

R&D open verdict? Winter 10

By Dr Kay Wardle
As pharmaceutical companies begin to shift from in-house R&D to external partnerships and ‘open innovation’, the traditional drug discovery model may soon be a thing of the past. In this ...