A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition

A novel assay specific for measuring inhibition of the P-glycoprotein multidrug transporter (PGp) is presented. The combination of the fast and simple fluorescence assay from the FluorosomeŽ company and the FLUOstar Omega microplate reader from BMG LABTECH is an ideal platform to screen for Pgp inhibitors in 96-well or 384-well format. Fluorescence kinetic signal curves and representative IC50 values for different test compounds are shown

Please click on the file in the right hand panel to download this Application Note.