Assay Services
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A strategic vision for 21ST CENTURY DRUG DISCOVERY
Delivering genuine therapeutic innovation is more challenging and complex than ever. Despite major scientific breakthroughs and technological advances leading to a greater understanding of the aetiology of diseases, it is generally accepted that the current approach to creating new small molecule therapeutics remains fundamentally inefficient.

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BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
The BlueScreen HCTM genotoxicity assay from Gentronix Ltd. uses a human-derived, p53-competent, TK6 cell line to host a luminescence-based reporter system that exploits the proper regulation of the GADD45a gene. GADD45a plays an important role in mediating the cellular response to genotoxic stress.

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DNA measurements in low volume samples, microplates and cuvettes on the SPECTROstar Nano
The SPECTROstar Nano offers different possibilities to measure DNA in UV absorbance mode. If there is enough DNA material available and only a few samples that should be measured, cuvette measurements can be performed. For higher throughput a microplate should be used. If sample volume is very limited, then the LVis Plate is recommended as it offers a great linear range, a high sensitivity and only 2 µl of sample is needed.

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Growth of Campylobacter using BMG LABTECH's FLUOstar Omega equipped with ACU
Growth of the fastidious microorganism Campylobacter jejuni was monitored using a FLUOstar Omega microplate reader equipped with the Atmospheric Control Unit (ACU). With the ACU it was possible to independently control the oxygen to 7 % and the carbon dioxide to 10 %. Growth curves obtained in 96-well microplates were comparable to conventional growth measurements where samples are taken and measured in cuvettes.

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Miniaturised Platelet Aggregation Assays using the NOVOstar Microplate Reader
Platelet aggregation is a “gold standard” assay of platelet function in the research and clinical laboratory settings which is conventionally measured with aggregometers requiring large volumes of platelet suspensions and only in low throughput format. With the NOVOstar microplate reader from BMG LABTECH we present an alternative optical method to measure platelet aggregation using small volumes in 96-well format.

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Bio-Rad Introduces New Bio-Plex Pro Magnetic Bead Based, Multiplex Immunoassays
Bio-Rad Laboratories, Inc. today announced the launch of new magnetic bead based multiplex immunoassays for TGF-?, rat cytokines, rat diabetes, and mouse TH17 cytokines.

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Quantitative, High- Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability
A Schistosoma viability assay (96 and 384 well format) is introduced that utilizes two fluorophores. Fluorescein diacetate emission is related to living cells while propidium iodide emission indicates the number of dead cells. This assay abandons low throughput microscopy and was performed in bottom reading mode on the POLARstar Omega microplate reader from BMG LABTECH.

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Cellular Dopamine and Intracellular Calcium Signaling Using the Next Generation HTS Microplate Reader
Two cell-based signaling assays from Invitrogen, Fluo-4 Direct™ Calcium Assay and Tango™-bla U2OS GPCR Assay, were performed on the PHERAstar FS HTS instrument. The PHERAstar FS has several unique features that enhance the performance of these assays including direct optic bottom reading, high resolution cell layer scanning, injection at the point of measurement and dual emission detection.

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Promega introduces custom assay services for biologics and small molecule drug discovery By Dr Neal Cosby, Promega Corp
The economics of contemporary drug discovery are forcing changes upon the industry at an alarming rate. Even academic and government laboratories are getting into the drug discovery game. Many of the larger pharmaceutical companies at least are turning to academia for their expertise in target identification and target validation.

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A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition
A novel assay specific for measuring inhibition of the P-glycoprotein multidrug transporter (PGp) is presented. The combination of the fast and simple fluorescence assay from the Fluorosome® company and the FLUOstar Omega microplate reader from BMG LABTECH is an ideal platform to screen for Pgp inhibitors in 96-well or 384-well format. Fluorescence kinetic signal curves and representative IC50 values for different test compounds are shown

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Assay Services
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