Drug Discovery World (DDW), the Quarterly Business Review of Drug Discovery & Development

LATEST ISSUE: SPRING 2017 Archive

Tackling multi-drug resistant bacteria

By Dr Ankit Mahadevia

Antibiotic resistance never should have become the public health crisis we are seeing today. As a society, we thought the problem of bacterial infections had been solved decades ago when more than 200 powerful antibiotics representing different classes such as -lactam, tetracyclines and macrolides were developed.

Advancing the drug discovery pipeline with early stage In vitro ADME and toxicity testing

By Dr Maureen Bunger

With increasing pressures on pharmaceutical companies to develop new, effective therapeutics across the board, and keep the costs of development down, the drug discovery industry needs to ensure that its standard processes and procedures are as streamlined and effective as possible.

Long-read sequencing offers path to more accurate drug metabolism profiles

By Dr Jenny Ekholm

In the complex drug discovery process, one of the looming questions for any new compound is how it will be metabolised in a human body. While there are several methods for evaluating this, one of the most common involves CYP2D6, the enzyme encoded by the cytochrome P450-2D6 gene.

New approaches to sample identification tracking and technologies for maintaining the quality of stored samples

By Dr John Comley

Safeguarding the quality of stored samples (both compounds and biospecimens) must be the driving ethos in compound management stores and biorepositories.

Raising the bar on the biologics potential

Dr Michael Mouradian

In the quest for safe, efficacious and profitable therapies, pharma research is changing. There is continued pressure to fill the drug pipeline and, at the same time, globalisation of personalised medicines is complex, expensive and requires a significant time commitment.

The rise of immunotherapies - strategies to accelerate their advance into clinical trials

By Edward Cribb

The striking rise of immunotherapies in the past decade has had a transformative effect on cancer treatment. Also referred to as biologic therapies, immunotherapies are a new class of drug that harnesses the potential of the body's immune system to target and destroy tumours.

UX Design maximising the value of scientific software in life science R&D

By Dr Jennifer Cham & Katrina Costa

Using scientific software can be frustrating and time-consuming, resulting in less productive research. This article aims to demonstrate that User Experience (UX) Design offers specific efficiency benefits for life science R&D.

The importance of heterocyclic compounds in anti-cancer drug design

By Simon Pearce

Heterocycles are key structural components of many of the anti-cancer drugs available on the market today. Indeed, of the novel molecular anti-cancer agents approved by the FDA between 2010 and 2015, almost two-thirds contained heterocyclic rings within their structures.

TTP Ventus introduces pressure-driven flow system for point-of-care diagnostics

New spin-out from TTP plc has developed second generation Disc Pump technology, with proven applications in medical devices, healthcare, and scientific research.

BenevolentAI Hires New Head of ChemInformatics from the Institute of Cancer Research

One of the world's largest private AI companies - BenevolentAI, that develops and applies AI for scientific innovation, has hired Dr Nathan Brown, as its new Head of Cheminformatics.

LifeArc negotiates exclusive licence deal with Nemysis Limited for oral iron supplement technology

LifeArc, the medical research charity formerly known as MRC Technology, has announced it has negotiated a licence for an oral iron supplement technology with Nemysis Limited (Nemysis).

New Thermo Scientific Samco Leakproof Vials Offer Enhanced Sample and User Safety

A new series of leakproof vials has been developed to provide sample protection and user safety by enabling correct cap application every time.

Thermo Fisher Scientific and SRI International Collaborate to Enhance Small Molecule Research

Thermo Fisher Scientific Inc. and SRI International, have announced the results of a collaboration agreement to enable researchers to combine the results of high-resolution Orbitrap LC/MS experiments with highly curated and organism-specific metabolic pathway and genome data for quick and effective mass spectrometry-based small molecule research and analysis.

Owlstone Medical and Cancer Research UK Initiate Pan Cancer Clinical Trial

The trial aims to evaluate Breath Biopsy for Early Detection of Disease and to identify breath biomarkers to improve the early detection and diagnosis of different cancer types.

	Drug Discovery	Business	Chemistry	Enabling Technologies
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	SpectraMax i3 Multi-Mode Detection System See how you can do more with your microplate reader than you ever imagined.

	Bioanalysis of Oxytocin Ultrasensitive Quantification Assay for Oxytocin in Human Plasma Using an LC/MS Microfluidics Platform